Effects of Piper sarmentosum on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

Piper sarmentosum (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant anti-inflammatory properties. Given that oxidative stress inflammation are involved in developing exacerbating metabolic syndrome (MetS) principal components (central obesity, hyperglycaemia, hypertension, dyslipidaemia), PS could manage MetS complications. This review summarises the available literature on effects of their The accumulated evidence suggests prevented adiposity, dyslipidaemia preclinical studies mainly through also protected MetS-associated cardiovascular has identified research gaps this field suggested future guide interested researchers explore further or affirm therapeutic potential PS. One most significant challenges medical use absence randomised controlled trials humans. study gap must be bridged before supplementation